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Hedgehog pathway inhibitor

Glasdegib (Specialist drug)

Brand names: Daurismo

Glasdegib is an oral Hedgehog pathway inhibitor used, in combination with low-intensity chemotherapy, to treat newly diagnosed acute myeloid leukaemia in adults not suitable for intensive induction.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It inhibits the Smoothened (SMO) transmembrane protein, blocking aberrant Hedgehog signal transduction implicated in leukaemic stem-cell maintenance.

Prescribing in practice

  • It is embryotoxic and teratogenic, so pregnancy must be excluded and effective contraception used by patients of childbearing potential during and after treatment per the SPC.
  • Treatment is initiated and supervised by specialists experienced in the management of acute leukaemia.
  • QT-interval prolongation can occur, so ECG and electrolytes should be checked and interacting QT-prolonging or CYP3A4 drugs reviewed.

Monitoring

Monitor full blood count, electrolytes and ECG (QT interval) periodically during treatment.

Counselling the patient

  • Use reliable contraception and do not donate blood or semen during and for the advised period after treatment.
  • Report palpitations or fainting, and expect possible muscle cramps and taste changes.
  • Attend all blood tests and heart-tracing appointments.

Evidence & guidelines

Combination benefit in unfit AML was shown in the BRIGHT AML 1003 randomised controlled trial.

Reference: NICE TA642; SmPC; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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