Endocrinology Pathways

19 pathways

Work through 19 interactive endocrinology decision pathways — branching, guideline-grounded workflows that take you from presentation to assessment, risk stratification and management. Each pathway cites its source (NICE, ESC, AHA and specialty guidance), embeds the relevant calculators, and makes escalation and safety-netting explicit. For decision support only — apply clinical judgement and local protocols.

Type 2 Diabetes Management

Step-up pharmacotherapy for T2DM — NICE NG28 individualised approach with HbA1c targets

NICE NG28 2022
Hyperthyroidism Management

Diagnosis and treatment of hyperthyroidism — Graves', toxic nodule, thyroiditis

BTA / ETA 2018
Adrenal Insufficiency

Diagnosis and management of adrenal insufficiency including sick-day rules and adrenal crisis

Society of Endocrinology / ESE 2016
Pituitary Apoplexy

Emergency management of pituitary apoplexy — haemorrhage or infarction of pituitary adenoma

ENEA 2011 / Pituitary Society
Hypercalcaemia Management

Diagnosis and treatment of hypercalcaemia — PTH-mediated vs malignancy

NICE / Endocrine Society
Hyperosmolar Hyperglycaemic State (HHS)

Hyperosmolar Hyperglycaemic State (HHS) clinical pathway.

NICE; JBDS; RCP — NG18
Thyroid Storm

Thyroid Storm clinical pathway.

American Thyroid Association; RCP — Best Practice
Myxoedema Coma

Decompensated severe hypothyroidism — hypothermia, hypotension, hypoventilation, ALOC. IV levothyroxine + hydrocortisone, supportive care.

Society for Endocrinology Emergency Guidance
Phaeochromocytoma — Diagnosis & Crisis

Workup with metanephrines, alpha-blockade BEFORE beta-blocker, surgery; manage crisis with phentolamine.

Endocrine Society 2014
Cushing's Syndrome Workup

Confirm hypercortisolism (LDDST, urinary cortisol, late-night salivary), distinguish ACTH-dependent vs independent, localise source.

Endocrine Society 2008/2015
Primary Aldosteronism

Common cause of resistant hypertension — screen aldosterone:renin ratio, confirm with saline suppression, lateralise with adrenal vein sampling.

Endocrine Society 2016
Hypopituitarism Management

Anterior + posterior pituitary deficiencies — prioritise cortisol replacement first, then thyroid, sex steroids, GH, ADH; sick-day rules.

Endocrine Society 2016; Society for Endocrinology
Hyperprolactinaemia / Prolactinoma

Confirm true hyperprolactinaemia, exclude drug/secondary, MRI, dopamine agonist (cabergoline) first-line.

Endocrine Society 2011
Hypocalcaemia (Adult)

Recognise tetany, ECG changes, IV calcium gluconate, identify cause (vitamin D, hypoparathyroidism, hyperphosphataemia, drugs).

Society for Endocrinology
Acromegaly

Diagnosis (IGF-1, OGTT GH suppression), pituitary MRI, transsphenoidal surgery first-line, somatostatin analogues / pegvisomant, comorbidity management.

Endocrine Society 2014
SIADH (Endocrine Perspective)

Schwartz-Bartter criteria, identify cause (CNS, pulmonary, drugs, malignancy), fluid restriction, salt + urea, tolvaptan.

European Hyponatraemia Guidelines 2014
Diabetes Insipidus

Polyuria + polydipsia with low urine osmolality — water deprivation test, distinguish central vs nephrogenic, desmopressin (central) or thiazide (nephrogenic).

Endocrine Society
Polycystic Ovary Syndrome (PCOS)

Rotterdam criteria, exclude differentials, lifestyle + metformin / OCP / clomiphene / letrozole, screen for cardiometabolic risk.

International PCOS Guideline 2023; NICE CKS
Hashimoto's / Hypothyroidism Management

Confirm with TSH + fT4 + TPO antibody, levothyroxine titration, special situations (pregnancy, elderly, ischaemic heart disease).

NICE NG145; BTA 2023