Endocrinology
Diabetes Insipidus
Polyuria + polydipsia with low urine osmolality — water deprivation test, distinguish central vs nephrogenic, desmopressin (central) or thiazide (nephrogenic).
Source: Endocrine Society
Used in: Diabetes & DKA
Step 1 of ~6
info
Recognise
Polyuria (>3 L/24h or >40 mL/kg/day) + polydipsia + hypernatraemia (if water access limited) + dilute urine. Differentials: primary polydipsia (psychogenic), osmotic diuresis (DM, mannitol). Bloods: U&E, glucose, calcium, paired plasma + urine osmolality (early morning).
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Irbesartan with hydrochlorothiazide · ARB + thiazide
- Lisinopril with hydrochlorothiazide · ACE inhibitor + thiazide
- Losartan with hydrochlorothiazide · ARB + thiazide
- Olmesartan with amlodipine and hydrochlorothiazide · ARB + CCB + thiazide triple
- Olmesartan with hydrochlorothiazide · ARB + thiazide
- Perindopril arginine with indapamide · ACE inhibitor + thiazide-like diuretic
Pathways
- Diabetic Ketoacidosis (DKA) · JBDS 2013 / Joint British Diabetes Societies; NICE NG17
- Adult Hypoglycaemia (Treated Diabetes) · JBDS-IP (2023): Hospital Management of Hypoglycaemia
- Adrenal Crisis · Society for Endocrinology Emergency Guidance (2024)
- Type 2 Diabetes Management · NICE NG28 2022
- Hyperthyroidism Management · BTA / ETA 2018
- Adrenal Insufficiency · Society of Endocrinology / ESE 2016
Decision support only. Always apply local guidelines and clinical judgement.