Haematology
Thrombotic Microangiopathy (TTP / HUS / aHUS)
MAHA + thrombocytopenia — TTP (ADAMTS13), HUS (Shiga toxin / atypical), drug-induced — urgent plasma exchange for TTP.
Source: BSH 2023; KDIGO
Step 1 of ~7
info
Recognise — MAHA + Thrombocytopenia
Microangiopathic haemolytic anaemia (MAHA — schistocytes on blood film, ↑ LDH, ↓ haptoglobin, ↑ bilirubin, negative Coombs) + thrombocytopenia + organ injury. Pentad (TTP — rarely all 5): MAHA + thrombocytopenia + AKI + neurological signs + fever. Differentials: TTP, STEC-HUS, atypical HUS, drug-induced TMA (calcineurin inhibitors, gemcitabine, ticlopidine, quinine), HIV, malignant hypertension, scleroderma renal crisis, transplant-associated, DIC, eclampsia/HELLP, antiphospholipid syndrome.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Factor XIII (Specialist drug) · Plasma-derived factor XIII concentrate
- Fibrinogen (Specialist drug) · Plasma-derived fibrinogen concentrate
- Protein C (Specialist drug) · Recombinant/plasma-derived protein C concentrate
- Von Willebrand factor (Specialist drug) · Plasma-derived or recombinant vWF concentrate
- Phenylephrine · Alpha-1 Adrenergic Agonist (Pure Vasoconstrictor)
- Gelatin (succinylated) · Colloid plasma volume expander
Pathways
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO
Decision support only. Always apply local guidelines and clinical judgement.