Plasma-derived or recombinant vWF concentrate
Von Willebrand factor (Specialist drug)
Brand names: Wilate, Voncento, Veyvondi
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV
Frequency: per indication
Clinical pearls
- Von Willebrand disease — bleeding episodes / surgical prophylaxis
- Specialist haem
Contraindications
- Hypersensitivity
- HIT (heparin-containing products)
Side effects
- Allergic reactions
- Thromboembolism (high doses)
- Headache
- Pyrexia
Monitoring
- FVIII:C
- vWF:RCo
- Bleeding
Reference: BNF; UK Haemophilia Society; SmPC; https://bnf.nice.org.uk/drugs/von-willebrand-factor-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Vancomycin Dosing Calculator · Drug Dosing
- Phenytoin Correction for Albumin / Renal Failure · Drug Dosing
- Local Anaesthetic Maximum Dose Calculator · Drug Dosing
- Tisdale Risk Score for QT Prolongation · Arrhythmia
- Bazett Corrected QT Interval (QTc) Calculator · Arrhythmia
- DAPT Score for Dual Antiplatelet Therapy Duration · Antiplatelet Therapy
Pathways
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO