Vancomycin Dosing Calculator
Calculates initial vancomycin dose based on weight and renal function. Target AUC/MIC 400–600 mg·h/L (ASHP/IDSA 2020 guidelines).
Score interpretation
Severely impaired renal clearance. Extended dosing intervals required.
→ Loading dose: 25 mg/kg IV. Extended interval dosing (every 48–96 hours or dialysis-dependent). Trough monitoring or AUC-guided dosing essential. Pharmacy consult recommended.
Reduced renal function. Adjust maintenance dose and interval.
→ Loading dose: 25 mg/kg IV. Maintenance: 15–20 mg/kg every 24–48 hours. Monitor levels; target AUC/MIC 400–600.
Near-normal or normal renal function. Standard weight-based dosing.
→ Loading dose: 25–30 mg/kg IV (max 3000 mg). Maintenance: 15–20 mg/kg every 8–12 hours. Target AUC/MIC 400–600. Pharmacy-guided TDM for severe infections.
Interpretation bands for the Vancomycin Dose. Apply clinical judgement and local guidance.
References
- Rybak MJ et al. Therapeutic monitoring of vancomycin for serious methicillin-resistant Staphylococcus aureus infections. Am J Health Syst Pharm. 2009;66(1):82-98.
- ASHP/IDSA/SIDP Vancomycin Consensus Guidelines 2020. Am J Health Syst Pharm. 2020;77(11):835-864.
Related
Curated clinical cross-links plus same-class fallbacks.
- Vancomycin (Renal Dosing) · Antibiotic Dosing in CKD
- Linezolid · Oxazolidinone — MRSA / VRE / Drug-Resistant TB (adjunct)
- Vancomycin (Paediatric) · Glycopeptide Antibiotic — MRSA / Severe Gram-Positive Infections in Children
- Vancomycin (Burns — MRSA) · Antibiotic — Glycopeptide
- Linezolid (Burns — Vancomycin-Resistant/Refractory MRSA) · Antibiotic — Oxazolidinone
- Gentamicin (Renal Dosing/TDM) · Antibiotic Dosing in CKD
- Infective Endocarditis · ESC 2023 Infective Endocarditis Guidelines; NICE NG41
- Eczema Herpeticum · BAD; NICE CKS
- Suspected Bacterial Meningitis (Adult) · NICE NG240 (2024); NICE NG143 (paeds)
- Clostridioides difficile Colitis · NICE NG199 (2021); IDSA/SHEA 2021
- Returning Traveller — Fever · NaTHNaC; PHE; ESCMID 2018
- Malaria — Diagnosis & Management · PHE 2016; WHO 2023
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.