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cardiology infectious-disease

2023 Duke-ISCVID Criteria for Infective Endocarditis

Updated 2023 Duke-ISCVID criteria for diagnosis of infective endocarditis (IE), replacing the original 2000 Duke criteria. Incorporates PET/CT and new pathogen definitions.

Score interpretation

Definite IE (Pathological)

→ Definite IE by pathological criteria: Histological/microbiological confirmation from surgery or autopsy. Ensure full antibiotic course; surgical findings guide management.

Definite IE (Clinical)

→ Definite IE (clinical): 2 major, 1 major + 3 minor, or 5 minor criteria. Full 4–6 week IV antibiotic therapy guided by microbiology. Cardiology + ID team involvement. Assess for surgical indications.

Possible IE

→ Possible IE: 1 major + 1 minor, or 3 minor criteria. Initiate empirical antibiotic therapy; repeat blood cultures; echocardiogram (TOE if TTE inadequate); cardiac surgery input.

IE Rejected

→ IE unlikely (rejected): Criteria not met. Consider alternative diagnosis. If high clinical suspicion persists, repeat cultures and imaging; re-evaluate after 5–7 days.

Interpretation bands for the Duke-ISCVID 2023. Apply clinical judgement and local guidance.

References

Related

Curated clinical cross-links plus same-class fallbacks.

📚 MRCEM Revision

Featured in these MRCEM clinical pathways

The Duke-ISCVID 2023 is covered in detail — with RCEM/NICE evidence base, indications and pitfalls — in the following exam-focused pathways on our sister siteReviseMRCEM.

MRCEM Primary / Intermediate / OSCE candidates: each pathway includes exam-style questions, RCEM/NICE citations, and FAQ summaries.

Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.