General Medicine A

Charlson Comorbidity Index (CCI) — Detailed

Detailed 17-condition comorbidity index predicting 10-year mortality. Age-adjusted version adds 1 point per decade after age 50.

Age Adjustment*

Myocardial infarction (history)*

Congestive heart failure*

Peripheral vascular disease*

Cerebrovascular disease (CVA or TIA)*

Dementia*

Chronic pulmonary disease (COPD, asthma)*

Connective tissue disease (RA, SLE, polymyositis)*

Peptic ulcer disease*

Mild liver disease (cirrhosis without portal hypertension, chronic hepatitis)*

Diabetes (without end-organ damage)*

Diabetes with end-organ damage (retinopathy, neuropathy, nephropathy)*

Hemiplegia*

Moderate/severe renal disease (eGFR <30 or dialysis)*

Any solid tumour (not metastatic, within last 5 years)*

Moderate/severe liver disease (portal hypertension, oesophageal varices)*

Metastatic solid tumour*

AIDS (not just HIV positive)*

References

Charlson ME et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373-383.
Quan H et al. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011;173(6):676-682.

Curated clinical cross-links plus same-class fallbacks.

Calculators

Drugs

Pathways

Decision support only — verify against MDCalc, NICE, or your local guideline before clinical use.