haematology
CARG Chemotherapy Toxicity Tool for Older Patients
Cancer and Aging Research Group (CARG) chemotherapy toxicity prediction tool. Predicts risk of grade 3-5 toxicity in patients aged 65 or above receiving chemotherapy. Score 0-3 = low risk (25% toxicity); 4-5 = intermediate (50%); 6 or above = high risk (70%). Validated by Hurria et al. 2011 in 500 patients across 7 cancer centres. Guides dose modification and geriatric support decisions.
References
- Hurria A et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol. 2011;29(25):3457-3465.
- Extermann M et al. Predicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score. Cancer. 2012;118(13):3377-3386.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Cisplatin · Platinum Chemotherapy — Head and Neck Cancer
- Dopamine (ICU — Vasopressor/Inotrope) · Catecholamine (Dose-Dependent Vasopressor/Inotrope)
- Hydroxocobalamin (High-Dose — Cyanide Antidote) · Cyanide Antidote (Vitamin B12 Precursor at High Dose)
- Dopamine hydrochloride · Inotrope / vasopressor (dose-dependent)
- Enalapril with hydrochlorothiazide · ACE inhibitor + thiazide diuretic (fixed-dose)
- Amiloride with Bumetanide · Potassium-Sparing Diuretic + Loop Diuretic (Fixed-Dose Combination)
Pathways
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO
- Anticoagulation Reversal · BSH 2016 / ESC
Decision support only — verify against MDCalc, NICE, or your local guideline before clinical use.