haematology
Peripheral Blood Stem Cell (PBSC) Collection Target Calculator
Calculates the target CD34+ cell collection dose required for autologous or allogeneic peripheral blood stem cell (PBSC) transplantation. Standard autologous HSCT target: 2-5 x 10^6 CD34+ cells/kg. Optimal target: 4-5 x 10^6 CD34+/kg. Minimum for engraftment: 2 x 10^6 CD34+/kg. Allogeneic: 4-8 x 10^6 CD34+/kg depending on centre protocol.
References
- Mohty M, Ho AD. In and out of the niche: perspectives in mobilization of hematopoietic stem cells. Exp Hematol. 2011;39(5):467-475.
- FACT-JACIE International Standards for Hematopoietic Cellular Therapy. 7th Edition. 2018.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Oxycodone with naloxone · Strong opioid + peripheral opioid antagonist
- Sodium Cromoglicate Nasal Spray · Mast Cell Stabiliser — Allergic Rhinitis
- Olopatadine · H1 antihistamine + mast cell stabiliser
- Loperamide · Opioid Receptor Agonist (Peripheral — Antidiarrhoeal)
- Alendronic Acid (Alendronate) · Bisphosphonate (bone resorption inhibitor)
- Domperidone · Prokinetic Antiemetic (Peripheral Dopamine Antagonist)
Pathways
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO
Decision support only — verify against MDCalc, NICE, or your local guideline before clinical use.