Furosemide Stress Test (FST) for AKI Progression
Functional test predicting progression to severe AKI / RRT (Chawla 2013, ARISE protocol 2020). Single-dose furosemide 1.0 mg/kg (loop-naïve) or 1.5 mg/kg (prior loop) IV; measure 2-hour urine output. Output <200 mL in 2 h indicates non-responsiveness and high risk of progression.
Score interpretation
→ Conservative AKI care: stop nephrotoxics, optimise volume, monitor U&E 12-hourly. ~75% will not progress to KDIGO 3.
→ Repeat at 4 h; close monitoring; consider early renal review. Prepare for possible RRT.
→ Early CRRT planning. Nephrology / ICU joint review. Vascular access (vascath); avoid nephrotoxics; consider biomarker testing (NGAL, TIMP-2 × IGFBP-7). KDIGO bundle.
Interpretation bands for the Furosemide Stress Test. Apply clinical judgement and local guidance.
References
Related
Curated clinical cross-links plus same-class fallbacks.
- Furosemide (IV — ICU) · Loop Diuretic
- Hydrocortisone (ICU — Stress Dosing) · Corticosteroid (ICU/Septic Shock)
- Furosemide · Diuretic
- Dobutamine (Acute HF / Stress Echo) · Inotrope / Acute Heart Failure
- Amiloride hydrochloride · Potassium-sparing diuretic (epithelial Na+ channel blocker)
- Furosemide with triamterene · Loop diuretic + potassium-sparing
- Hyperkalaemia Management · UK Kidney Association Guidelines 2020; NICE CKD Guidelines
- Rhabdomyolysis · Renal Association 2018; UpToDate 2024
- Hypocalcaemia (Adult) · Society for Endocrinology
- SIADH (Endocrine Perspective) · European Hyponatraemia Guidelines 2014
- Hepatorenal Syndrome · EASL 2018; ICA 2015
- Acute Kidney Injury (AKI) · KDIGO 2012 / NICE AKI 2019
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.