Renal Emergency Medicine Moderate — useful but limitations acknowledged in severe CKD
Transtubular Potassium Gradient (TTKG)
Estimates aldosterone activity by assessing potassium secretion in the collecting duct. Used to differentiate causes of hyperkalaemia (renal vs extra-renal) and hypokalaemia.
References
- Ethier JH, et al. The transtubular potassium concentration in patients with hypokalemia and hyperkalemia. Am J Kidney Dis. 1990;15(4):309–315.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Drugs
- Spironolactone · Aldosterone antagonist (potassium-sparing diuretic)
- Spironolactone (Ascites / Cirrhosis) · Aldosterone Antagonist / Potassium-Sparing Diuretic
- Potassium Chloride (IV) · Electrolyte — Potassium Supplement
- Amiloride hydrochloride · Potassium-sparing diuretic (epithelial Na+ channel blocker)
- Co-amilofruse · Loop diuretic + potassium-sparing
- Co-amilozide · Thiazide + potassium-sparing
Pathways
- Hyperkalaemia Management · UK Kidney Association Guidelines 2020; NICE CKD Guidelines
- Acute Kidney Injury (AKI) · KDIGO 2012 / NICE AKI 2019
- CKD Management · NICE CKD 2021 / KDIGO 2024
- Nephrotic Syndrome · KDIGO 2021
- RRT Initiation · KDIGO 2012 / NICE
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
Decision support only — verify against MDCalc, NICE, or your local guideline before clinical use.