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Loop diuretic + potassium-sparing

Co-amilofruse

Brand names: Frumil, Lasoride

Adult dose

Dose: 1 tab (5mg amiloride / 40mg furosemide) OD; up to 2 tabs/day
Route: PO
Frequency: OD

Clinical pearls

  • Heart failure when furosemide alone causes hypokalaemia
  • Monitor K+ and renal function

Contraindications

  • Hyperkalaemia
  • Anuria
  • Addison's disease
  • Severe renal impairment

Side effects

  • Hyperkalaemia
  • Hyponatraemia
  • Hypovolaemia
  • Postural hypotension
  • Gout

Interactions

  • ACEi/ARB/spironolactone (hyperkalaemia)
  • NSAIDs (reduced effect, renal)
  • Lithium toxicity
  • Digoxin (toxicity if hypokalaemia rare here)

Monitoring

  • U&E
  • Weight

Reference: BNF; https://bnf.nice.org.uk/drugs/co-amilofruse/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.