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Cardioselective beta-blocker (β1 + β2 partial agonist)

Celiprolol hydrochloride

Brand names: Celectol

Adult dose

Dose: 200–400mg OD
Route: Oral
Frequency: OD

Clinical pearls

  • NICE NG136 hypertension
  • Specific role in vascular Ehlers-Danlos syndrome (RCP / EDS Society — reduces aortic events)
  • ESC HT guidelines

Contraindications

  • Severe asthma
  • Decompensated HF
  • Severe bradycardia / heart block
  • Phaeochromocytoma without alpha-block

Side effects

  • Fatigue
  • Bradycardia
  • Bronchospasm (less than non-selective)
  • Hypotension
  • Cold extremities

Interactions

  • Verapamil/diltiazem
  • Insulin/oral hypoglycaemics

Monitoring

  • BP
  • HR
  • Symptoms

Reference: BNF; NICE NG136; RCP / EDS guidance; ESC HT; https://bnf.nice.org.uk/drugs/celiprolol-hydrochloride/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.