ACE inhibitor
Fosinopril sodium
Brand names: Staril
Adult dose
Dose: Hypertension/HF: initial 10mg OD, titrate to 20–40mg OD (max 40mg)
Route: PO
Frequency: OD
Clinical pearls
- Dual hepatic/renal elimination — useful in mild renal impairment
- Black patients: prefer CCB/thiazide first-line per NICE NG136
Contraindications
- History of angioedema
- Bilateral renal artery stenosis
- Pregnancy
Side effects
- Cough
- Hyperkalaemia
- Renal impairment
- Angioedema (rare but more frequent in Black patients)
- First-dose hypotension
Interactions
- NSAIDs
- Potassium-sparing diuretics
- Lithium
- Sacubitril/valsartan (avoid concurrent — angioedema)
Monitoring
- U&E
- BP
Reference: BNF; NICE NG136; https://bnf.nice.org.uk/drugs/fosinopril-sodium/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- SMART Risk Score for Recurrent CVD · Cardiovascular Risk
- PCSK9 Inhibitor Eligibility Assessment · Lipid Management
- Corrected Sodium (Hyperglycaemia) · Electrolytes
- Hyponatraemia Cause Algorithm · Electrolyte Disorders
- MELD-Na Score · Liver Disease
- Immune-Related Adverse Events (irAE) -- GI Toxicity Colitis Grading · Oncology-Related GI
Drugs
Pathways
- Acute Heart Failure · ESC 2021 Heart Failure Guidelines; NICE NG106
- NSTEMI / Unstable Angina · ESC 2020 NSTEMI Guidelines; NICE NG185
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines