ACE inhibitor
Trandolapril
Brand names: Gopten, Odrik
Adult dose
Dose: Initial 0.5–1mg PO OD; titrate to 1–4mg OD
Route: PO
Frequency: OD
Dose adjustments
Renal
Reduce in renal impairment
Clinical pearls
- Hypertension, post-MI LV dysfunction
- Long half-life via active metabolite
Contraindications
- Pregnancy
- Bilateral renal artery stenosis
- Hereditary angioedema
- ACEi angioedema
Side effects
- Dry cough
- Hyperkalaemia
- Hypotension
- Renal impairment
- Angioedema
Interactions
- NSAIDs
- K-sparing diuretics
- Lithium
- ARBs
Monitoring
- U&E
- BP
Reference: BNF; NICE NG136; https://bnf.nice.org.uk/drugs/trandolapril/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- SMART Risk Score for Recurrent CVD · Cardiovascular Risk
- PCSK9 Inhibitor Eligibility Assessment · Lipid Management
- Immune-Related Adverse Events (irAE) -- GI Toxicity Colitis Grading · Oncology-Related GI
- irAE Hepatitis Grading (CTCAE) · Immunotherapy
- DIPSS — Dynamic International Prognostic Scoring System for Myelofibrosis · Cancer Prognosis
- BALL Score for Relapsed/Refractory CLL · Leukaemia
Drugs
Pathways
- Acute Heart Failure · ESC 2021 Heart Failure Guidelines; NICE NG106
- NSTEMI / Unstable Angina · ESC 2020 NSTEMI Guidelines; NICE NG185
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines