Chlorhexidine gluconate with isopropyl alcohol

How it works

Chlorhexidine disrupts microbial cell membranes and gives persistent residual activity, while isopropyl alcohol denatures proteins for rapid, broad-spectrum kill, the combination acting faster and more durably than either alone.

Prescribing in practice

• The solution is flammable, so it must be allowed to dry fully and pooling avoided before diathermy or other ignition sources are used, to prevent surgical fires.
• Avoid contact with the eyes, middle ear and meninges, and use with care on broken skin and in neonates where chemical burns have been reported.
• Chlorhexidine can rarely cause anaphylaxis, so check for known hypersensitivity.

Monitoring

Confirm the prepared skin is fully dry before draping or using electrosurgery and observe for any local irritation or hypersensitivity reaction.

Counselling the patient

• For external skin preparation only — keep away from the eyes and ears.
• Allow the skin to dry completely before any procedure involving heat or electrical instruments.

Evidence & guidelines

MHRA and patient-safety guidance highlight fire risk from incomplete drying and pooling of alcohol-based skin antiseptics; use follows the SPC.