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Potent topical corticosteroid

Fluocinolone acetonide

Brand names: Synalar

Fluocinolone acetonide is a potent topical corticosteroid used for inflammatory skin conditions such as eczema and psoriasis, available in formulations including a scalp application.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It activates intracellular glucocorticoid receptors, producing anti-inflammatory, immunosuppressive and vasoconstrictive effects within the skin.

Prescribing in practice

  • As a potent steroid, prolonged use or application to the face, flexures or under occlusion increases the risk of skin atrophy and systemic absorption; use the lowest effective potency for the shortest duration.
  • Lower-strength formulations are preferred for delicate sites such as the face and skin folds.
  • Do not apply to untreated bacterial, fungal or viral skin infection.

Monitoring

No routine laboratory monitoring is required; review for clinical response and local corticosteroid adverse effects.

Counselling the patient

  • Apply thinly to affected areas only and avoid the face and skin folds unless directed.
  • Stop and seek advice if the skin shows signs of infection.
  • Continue regular emollients between steroid applications.

Evidence & guidelines

Topical corticosteroids of appropriate potency are recommended in NICE eczema and psoriasis guidance, tailored to severity and site.

Reference: NICE CG57; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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