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Antiseptic / astringent

Potassium permanganate

Potassium permanganate is a topical antiseptic and astringent used as a soak or compress for weeping, exudative or infected skin conditions such as wet eczema, leg ulcers and bullous disorders.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It is an oxidising agent with antiseptic and astringent properties that helps dry out exudate and reduce bacterial load on weeping skin.

Prescribing in practice

  • It must be diluted to a pale pink solution before use; concentrated solutions, undissolved crystals or tablets are corrosive and cause chemical burns.
  • It is for external use only and stains skin, nails, fabrics, baths and surfaces brown.
  • Soaks are typically used for a limited period until exudation settles, then stopped, as prolonged use can dry and irritate the skin.

Monitoring

Review the skin for reduced exudate and for signs of over-drying or irritation, discontinuing once the surface has settled.

Counselling the patient

  • Always dilute fully to a pale pink colour and never apply neat or use undissolved tablets or crystals.
  • It is for soaking the skin only and will stain skin, nails and anything it touches brown.
  • Use only for the short period advised, as overuse dries the skin.

Evidence & guidelines

Potassium permanganate soaks are a long-standing recommended option for weeping and exudative skin conditions, supported by clinical experience and the SPC.

Reference: NICE CKS; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.