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Antihistamine (H1, second-generation, non-sedating)

Bilastine

Brand names: Ilaxten

Bilastine is a non-sedating second-generation H1 antihistamine used for allergic rhinoconjunctivitis and urticaria.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It is a selective peripheral histamine H1 receptor antagonist that suppresses histamine-mediated allergic symptoms.

Prescribing in practice

  • It should be taken on an empty stomach because food and fruit juices substantially reduce its absorption.
  • It undergoes minimal hepatic metabolism and is largely excreted unchanged, which limits relevant drug interactions.
  • Concurrent use with certain transporter-inhibiting drugs may increase its plasma levels.

Monitoring

Routine monitoring is not required; review symptom control clinically.

Counselling the patient

  • Take at least one hour before or two hours after food or fruit juice.
  • Report any unexpected drowsiness.
  • Use regularly during allergy season for best symptom control.

Evidence & guidelines

Second-generation antihistamines such as bilastine are recommended first-line for allergic rhinitis and chronic urticaria in current guidance.

Reference: SmPC Ilaxten; BSACI Rhinitis Guideline 2017; EAACI/GA²LEN Urticaria Guideline 2022; Confirm identity and dosing against the manufacturer SPC (eMC) and NICE. Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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