Antihistamine (H1, second-generation, non-sedating)

Desloratadine

Brand names: Neoclarityn, Aerius

Desloratadine is a non-sedating second-generation H1 antihistamine, the active metabolite of loratadine, used for allergic rhinitis and chronic urticaria.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It is a selective peripheral histamine H1 receptor antagonist that inhibits the effects of histamine released in allergic reactions.

Prescribing in practice

Although usually non-sedating, patients should be cautioned that drowsiness can occur and may affect driving or skilled tasks.
It can be taken once daily with or without food, which supports adherence.
Caution is advised in severe renal or hepatic impairment.

Monitoring

No routine monitoring is required; assess symptom control clinically.

Counselling the patient

Take once daily and report any drowsiness.
It can be taken with or without food.
Use regularly during the allergy season for best effect.

Evidence & guidelines

Second-generation antihistamines such as desloratadine are recommended first-line for allergic rhinitis and chronic urticaria in current guidance.

Reference: SmPC Neoclarityn / Aerius; BSACI Rhinitis Guideline 2017; EAACI/GA²LEN Urticaria Guideline 2022; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Curated clinical cross-links plus same-class fallbacks.

Calculators

Drugs

Bilastine · Antihistamine (H1, second-generation, non-sedating)

Pathways