Second-generation H1-antihistamine + PAF antagonist

Rupatadine

Brand names: Rupafin

Rupatadine is a non-sedating oral antihistamine used to treat allergic rhinitis and chronic urticaria.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It is a long-acting selective histamine H1-receptor antagonist with additional platelet-activating factor antagonism, reducing the symptoms of allergic and histamine-mediated reactions.

Prescribing in practice

Although classed as non-sedating, drowsiness can still occur, and concomitant alcohol or CNS depressants may add to this effect.
It is metabolised by CYP3A4, so caution is advised with potent enzyme inhibitors such as certain azole antifungals and macrolides.
Grapefruit juice may increase exposure and should be avoided.

Monitoring

No routine monitoring is required; review if allergic symptoms remain inadequately controlled.

Counselling the patient

If it makes you drowsy, avoid driving or operating machinery and be careful with alcohol.
Avoid grapefruit juice while taking this medicine.
It can be taken regularly to help control ongoing allergy symptoms.

Evidence & guidelines

Use is supported by its established role in allergic rhinitis and chronic urticaria; consult current prescribing references for interaction details.

Reference: SmPC; Confirm identity and dosing against the manufacturer SPC (eMC) and NICE. Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Curated clinical cross-links plus same-class fallbacks.

Calculators

Pathways