Albumin solution

How it works

Albumin is the major plasma protein contributing to colloid osmotic pressure; infused albumin expands the intravascular volume by drawing and retaining fluid within the circulation.

Prescribing in practice

• Use cautiously in patients at risk of circulatory overload, including those with cardiac failure or renal impairment, as rapid infusion can precipitate fluid overload and pulmonary oedema.
• Choose the appropriate concentration for the clinical purpose, as isotonic and concentrated preparations have different volume and oncotic effects.
• As a blood-derived product it carries a theoretical infection risk and must be prescribed and administered according to local transfusion and traceability policy.

Monitoring

Monitor blood pressure, fluid balance and signs of circulatory overload during and after infusion, with electrolytes and haemodynamic status as clinically indicated.

Counselling the patient

• This is a product made from human blood plasma given by a drip.
• Report any breathlessness, rash or feeling unwell during the infusion.
• The team will monitor your fluid balance closely.

Evidence & guidelines

Albumin use is informed by evidence such as the SAFE trial and guidance supporting its role in specific indications including spontaneous bacterial peritonitis and large-volume paracentesis.