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Proton Pump Inhibitor (PPI)

Lansoprazole

Brand names: Zoton FasTab

Lansoprazole is a proton-pump inhibitor used for gastro-oesophageal reflux disease, peptic ulcer disease, as part of Helicobacter pylori eradication, and for gastroprotection.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

US labelling (FDA)

Reference — US labelling, may differ from UK

Recommended Dosage: See full prescribing information for complete dosing information for lansoprazole delayed-release capsules by indication and age group and dosage adjustment in patients with severe hepatic impairment. ( 2.1 , 2.2 , 2.3 ) Administration Instructions ( 2.4 ) Lansoprazole delayed-release capsules Should be swallowed whole. See full prescribing information for alternative administration options 2.1 Recommended Adult Dosage by Indication Indication Recommended Dose Frequency Duodenal Ulcers Short-Term Treatment 15 mg Once daily for 4 weeks Maintenance of Healed 15 mg Once daily Eradication of H. pylori to Reduce the Risk of Duodenal Ulcer Recurrence* Triple Therapy: …

Source: US FDA prescribing information (openFDA / DailyMed), label dated 2022-04-15. Accessed 2026-06-12. US dosing and indications can differ from UK practice — use UK sources for prescribing decisions.

Clinical monograph

How it works

It irreversibly inhibits the gastric H-K-ATPase (proton pump) in parietal cells, strongly reducing gastric acid secretion.

Prescribing in practice

  • Use the lowest effective dose for the shortest appropriate duration; review long-term use.
  • Long-term effects can include low magnesium, reduced vitamin B12 absorption, and a small increase in some infections and fractures.
  • It can mask the symptoms of gastric cancer — investigate alarm features before attributing them to reflux.

Monitoring

No routine monitoring for short courses; consider checking magnesium with long-term use or with other magnesium-lowering drugs, and review the ongoing need periodically.

Counselling the patient

  • Take it before food (typically 30–60 minutes before a meal).
  • Tell your clinician about difficulty swallowing, unintended weight loss, or black stools.

Evidence & guidelines

PPIs are first-line for GORD and peptic ulcer disease and for NSAID-associated gastroprotection in at-risk patients (NICE guidance).

Reference: NICE CG17 GORD; NICE NG12 H. pylori; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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