Proton Pump Inhibitor (PPI)

Pantoprazole

Brand names: Protium

Pantoprazole is a proton-pump inhibitor used for gastro-oesophageal reflux disease, peptic ulcer disease, and gastroprotection.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

US labelling (FDA)

Reference — US labelling, may differ from UK

GERD and a History of EE Adults: The recommended dosage is 40 mg once daily by intravenous injection (over at least 2 minutes) or intravenous infusion (for 15 minutes) for up to 10 days. ( 2.1 ) Discontinue as soon as the patient is able to receive oral treatment. Switch to an appropriate oral medication within 10 days of starting pantoprazole sodium for injection. ( 2.1 ) Pathological Hypersecretion Conditions, Including ZE Syndrome The recommended adult dosage is 80 mg every 12 hours by intravenous injection (over at least 2 minutes) or intravenous infusion (for 15 minutes). ( 2.2 ) For information on how to adjust dosing for individual patient needs, see the full prescribing information. …

Source: US FDA prescribing information (openFDA / DailyMed), label dated 2025-06-27. Accessed 2026-06-12. US dosing and indications can differ from UK practice — use UK sources for prescribing decisions.

Clinical monograph

How it works

It irreversibly inhibits the gastric H-K-ATPase (proton pump) in parietal cells, strongly reducing acid secretion.

Prescribing in practice

Use the lowest effective dose for the shortest appropriate time, and review long-term use.
It has comparatively few CYP interactions among the PPIs; long-term effects can include low magnesium, reduced vitamin B12 absorption, and small increases in some infections and fractures.
It can mask the symptoms of gastric cancer — investigate alarm features.

Monitoring

No routine monitoring for short courses; consider magnesium with long-term use and review the ongoing need.

Counselling the patient

Take it before food.
Report difficulty swallowing, unintended weight loss, or black stools.

Evidence & guidelines

A PPI for GORD, peptic ulcer disease and gastroprotection, valued for relatively few drug interactions.

Reference: NICE CG141 Peptic Ulcer; ESC AFib PPI guidance; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Curated clinical cross-links plus same-class fallbacks.

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