Bowel preparation
Sodium acid phosphate with sodium bicarbonate
Adult dose
Dose: Per BNF/local protocol
Route: PO
Frequency: per indication
Clinical pearls
- Bowel preparation; PEG-based preparations preferred per NICE for safety
- Hydrate well; avoid in CKD/HF
Contraindications
- Severe renal impairment
- HF
- Severe colitis/megacolon
- Children <18 (most preparations)
Side effects
- Phosphate nephropathy
- Electrolyte disturbance
- Volume depletion
- Cardiac arrhythmias
Interactions
- ACE-i/ARB/diuretics/NSAIDs (AKI risk — avoid combination)
Monitoring
- U&E
- Phosphate
- ECG
Reference: BNF; NICE NG12; https://bnf.nice.org.uk/drugs/sodium-acid-phosphate-with-sodium-bicarbonate/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Pathways
- Lower Gastrointestinal Bleed · BSG 2019; NICE NG141
- Variceal Upper GI Bleed · BSG 2015; Baveno VII (2022)
- Spontaneous Bacterial Peritonitis (SBP) · BSG / EASL 2018
- Hepatorenal Syndrome · EASL 2018; ICA 2015
- Hepatic Encephalopathy · EASL 2014; West Haven criteria
- Clostridioides difficile Colitis · NICE NG199 (2021); IDSA/SHEA 2021