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Water-soluble vitamin K analogue

Menadiol sodium phosphate

Menadiol sodium phosphate is a water-soluble synthetic analogue of vitamin K used to prevent or treat vitamin K deficiency, particularly where fat malabsorption impairs absorption of the natural fat-soluble vitamin.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

After conversion in the body it supports hepatic gamma-carboxylation of vitamin K-dependent clotting factors (II, VII, IX and X), thereby restoring their coagulant activity.

Prescribing in practice

  • It should be avoided in neonates and infants and in glucose-6-phosphate dehydrogenase deficiency because it can provoke haemolytic anaemia and, in newborns, kernicterus.
  • It is not the agent of choice for reversing the effect of oral vitamin K antagonists such as warfarin.
  • It is particularly suited to vitamin K deficiency arising from fat malabsorption states because of its water solubility.

Monitoring

Monitor the coagulation profile, such as prothrombin time or INR, to assess the response to treatment.

Counselling the patient

  • This medicine replaces vitamin K when your body cannot absorb it properly.
  • Tell your clinician if you have a known red blood cell enzyme deficiency.

Evidence & guidelines

Its use is based on the well-established role of vitamin K in synthesis of clotting factors; prescribe according to current prescribing references.

Reference: Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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