Water-soluble vitamin K analogue
Menadiol sodium phosphate
Adult dose
Dose: 10mg/day PO
Route: PO
Frequency: OD
Clinical pearls
- Vitamin K deficiency where fat absorption impaired — water-soluble form
- Phytomenadione (K1) preferred for warfarin reversal
Contraindications
- Late pregnancy (haemolysis in neonate)
- G6PD deficiency
- Hypersensitivity
Side effects
- Haemolysis (esp. G6PD)
- Hyperbilirubinaemia in neonates
Interactions
- Warfarin (antagonism)
Reference: BNF; https://bnf.nice.org.uk/drugs/menadiol-sodium-phosphate/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Pathways
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO