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Recombinant FSH

Follitropin alfa

Brand names: Gonal-F, Bemfola, Ovaleap

A recombinant human follicle-stimulating hormone (follitropin alfa) used for ovarian stimulation in assisted reproduction and for ovulation induction and male hypogonadotrophic infertility.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

As recombinant FSH it stimulates ovarian follicular growth via FSH receptors on granulosa cells, and supports spermatogenesis in men.

Prescribing in practice

  • Ovarian hyperstimulation syndrome is the principal serious risk and mandates specialist supervision with response monitoring.
  • Multiple pregnancy and, less commonly, thromboembolic events are increased risks during stimulation cycles.
  • Administered by subcutaneous injection, often via pre-filled pen; exclude pituitary/ovarian tumours and untreated endocrine disease first.

Monitoring

Track follicular development with ultrasound and serum oestradiol to titrate dose and minimise hyperstimulation.

Counselling the patient

  • If self-injecting, follow the pen instructions on technique and storage.
  • Report abdominal pain, bloating, breathlessness or reduced urine output urgently.
  • Be aware of the increased chance of multiple pregnancy.

Evidence & guidelines

Recombinant FSH is an established gonadotrophin option within NICE-recommended assisted reproduction pathways.

Reference: NICE CG156; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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