GnRH analogue

Gonadorelin

Brand names: HRF

A synthetic form of gonadotrophin-releasing hormone (GnRH) used diagnostically to assess pituitary gonadotrophin reserve and in the investigation of hypothalamic-pituitary-gonadal function.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It stimulates GnRH receptors on the anterior pituitary to trigger release of luteinising hormone and follicle-stimulating hormone, allowing assessment of the gonadotrophin response.

Prescribing in practice

Hypersensitivity reactions can occur, so administer where appropriate monitoring and resuscitation facilities are available.
Used mainly as a diagnostic test of pituitary function, with sampling of LH and FSH before and after administration.
Continuous (non-pulsatile) GnRH receptor stimulation ultimately suppresses gonadotrophins, which is relevant when interpreting prolonged exposure.

Monitoring

Measure serum LH and FSH at defined timepoints around administration to interpret the pituitary response.

Counselling the patient

This is usually a short diagnostic test involving blood samples before and after the injection.
A brief flushing sensation or injection-site reaction may occur.
Report any signs of an allergic reaction.

Evidence & guidelines

Gonadorelin is used as an established diagnostic agent for pituitary gonadotrophin reserve in endocrine practice.

Reference: Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Curated clinical cross-links plus same-class fallbacks.

Drugs

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