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Human menopausal gonadotrophin (FSH+LH)

Menotrophin (HMG)

Brand names: Menopur, Merional

A human menopausal gonadotrophin preparation containing follicle-stimulating and luteinising hormone activity, used to stimulate follicular development in assisted reproduction and to treat anovulatory infertility.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

Its FSH and LH activity stimulates ovarian follicular growth, maturation and oestrogen production, mimicking endogenous gonadotrophin action.

Prescribing in practice

  • Use only under specialist supervision with cycle monitoring, because ovarian stimulation risks ovarian hyperstimulation syndrome and multiple pregnancy.
  • Tailor stimulation to the individual ovarian response using ultrasound and hormone results.
  • Exclude hormone-dependent tumours, uncontrolled thyroid or adrenal disorders, and other contraindications to ovulation induction before treatment.

Monitoring

Monitor follicular development with serial ultrasound and oestradiol levels to titrate dosing and reduce the risk of hyperstimulation and multiple pregnancy.

Counselling the patient

  • Report bloating, abdominal pain, nausea or reduced urine output, which may indicate ovarian hyperstimulation.
  • Be aware of the increased likelihood of multiple pregnancy with fertility treatment.
  • Keep to the planned schedule of injections and monitoring appointments.

Evidence & guidelines

Menotrophin is a long-established gonadotrophin used for ovulation induction and controlled ovarian stimulation, as described in assisted-reproduction practice and the SPC.

Reference: NICE CG156; Confirm identity and dosing against the manufacturer SPC (eMC) and NICE. Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

Pathways