Bruton's tyrosine kinase (BTK) inhibitor
Acalabrutinib [Specialist drug]
Brand names: Calquence
Adult dose
Dose: Specialist; typically 100 mg BD
Route: Oral
Frequency: Per SACT/SmPC
Clinical pearls
- CLL and MCL per haemato-oncology MDT; defer dosing to BNF/SmPC
Contraindications
- Concomitant strong CYP3A inhibitors (use alternatives)
Side effects
- Headache
- Bleeding
- Atrial fibrillation
- Cytopenias
- Infections
Interactions
- PPIs (avoid; spaced antacids/H2RAs allowed)
- Strong CYP3A modulators
Monitoring
- FBC
- ECG/AF
- Bleeding
Reference: BNF; NICE TA689/TA833; BSH; SmPC Calquence. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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