EGFR tyrosine-kinase inhibitor
Gefitinib (Specialist drug)
Brand names: Iressa
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC; usually 250mg OD
Route: PO
Frequency: OD
Clinical pearls
- EGFR-mutation-positive locally advanced/metastatic NSCLC
Contraindications
- Severe hepatic impairment
- Pregnancy
Side effects
- ILD (potentially fatal)
- Diarrhoea
- Acneiform rash
- Hepatotoxicity
- Corneal erosion
Interactions
- Strong CYP3A4 inhibitors/inducers
- Drugs raising gastric pH (PPIs, H2 antagonists) reduce levels
- Warfarin
Monitoring
- LFTs
- Symptoms of ILD
- Ophthalmic if eye symptoms
Reference: BNF; NICE TA192; SmPC; https://bnf.nice.org.uk/drugs/gefitinib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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