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Non-selective NSAID

Indometacin

Adult dose

Dose: 50–200mg/day in divided doses; max 200mg/day. Acute gout: 150–200mg/day initially. PDA closure (neonatal): specialist

Route: PO/PR/IV

Frequency: divided

Clinical pearls

Acute gout (alternative to colchicine/naproxen)
Neonatal PDA closure (specialist)

Contraindications

Active GI bleeding
Severe heart failure
Severe renal/hepatic impairment
Aspirin/NSAID hypersensitivity
Late pregnancy

Side effects

GI upset/bleeding
Headache
Renal impairment
Cardiovascular events
CNS effects (rare)

Interactions

Anticoagulants/antiplatelets
ACEi/ARB
Lithium
Methotrexate

Monitoring

U&E
FBC if prolonged

Reference: BNF; https://bnf.nice.org.uk/drugs/indometacin/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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