HER2/EGFR tyrosine-kinase inhibitor
Lapatinib (Specialist drug)
Brand names: Tyverb
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: OD
Clinical pearls
- HER2-positive metastatic breast cancer
- Take on empty stomach
Contraindications
- Severe hepatic impairment
- Pregnancy
Side effects
- Diarrhoea
- Hand-foot skin reaction
- Hepatotoxicity
- Cardiotoxicity (LV dysfunction)
- ILD
- QT prolongation
Interactions
- Strong CYP3A4 modulators
- QT-prolonging drugs
- Drugs raising gastric pH
Monitoring
- LFTs
- ECG
- Echo (LVEF)
Reference: BNF; NICE TA257; SmPC; https://bnf.nice.org.uk/drugs/lapatinib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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