3rd-generation EGFR tyrosine-kinase inhibitor
Lazertinib (Specialist drug)
Brand names: Lazcluze
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: OD
Clinical pearls
- EGFR-mutated NSCLC (often combined with amivantamab); specialist oncology
Contraindications
- See SmPC
Side effects
- Rash
- Paronychia
- Diarrhoea
- Hepatotoxicity
- ILD
- QT prolongation
- Cardiomyopathy
Interactions
- Strong CYP3A4 modulators
- QT-prolonging drugs
Monitoring
- LFTs
- ECG
- Echo
- Pulmonary symptoms
Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/lazertinib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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