Multi-kinase inhibitor (FLT3, KIT)
Midostaurin (Specialist drug)
Brand names: Rydapt
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: BD
Clinical pearls
- FLT3-mutated AML, advanced systemic mastocytosis
- Specialist haem-onc
Contraindications
- Concurrent strong CYP3A4 inducers
Side effects
- Pulmonary toxicity (ILD)
- QT prolongation
- Cytopenias
- Hepatotoxicity
- Severe nausea
Interactions
- Strong CYP3A4 modulators
- QT-prolonging drugs
Monitoring
- FBC
- LFTs
- ECG
- Pulmonary symptoms
Reference: BNF; NICE TA523; SmPC; https://bnf.nice.org.uk/drugs/midostaurin-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Sequential Organ Failure Assessment (SOFA) Score · Sepsis / Organ Failure
- Vancomycin Dosing Calculator · Drug Dosing
- Phenytoin Correction for Albumin / Renal Failure · Drug Dosing
- Local Anaesthetic Maximum Dose Calculator · Drug Dosing
- Multiple Organ Dysfunction Score (MODS) · Organ Failure Assessment
- Logistic Organ Dysfunction Score (LODS) · ICU Scoring
Pathways
- Acute Myeloid Leukaemia Presentation · BSH; NICE — NG146
- Tumour Lysis Syndrome · Cairo-Bishop; BSH; NICE — Best Practice
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158