Platinum chemotherapy
Oxaliplatin (Specialist drug)
Brand names: Eloxatin
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV
Frequency: per protocol
Clinical pearls
- Colorectal, gastric, pancreatic cancer; specialist oncology
- Counsel re cold-induced neuropathy (avoid cold drinks/exposure)
Contraindications
- Severe myelosuppression
- Severe peripheral neuropathy
- Severe renal impairment
- Pregnancy/breastfeeding
Side effects
- Peripheral neuropathy (cold-induced acute + cumulative chronic)
- Severe myelosuppression
- Nausea/vomiting
- Cardiotoxicity (rare)
- Hypersensitivity
- Pulmonary fibrosis
Interactions
- Aminoglycosides
- Other ototoxic/nephrotoxic drugs
Monitoring
- FBC
- Renal function
- Neurological exam
Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/oxaliplatin-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
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