Ciprofloxacin (UTI/Prostatitis)

Durations from the SPC table: uncomplicated cystitis 3 days (in pre-menopausal women, a 500 mg single dose may be used); complicated cystitis / uncomplicated pyelonephritis 7 days; complicated pyelonephritis at least 10 days, and can be continued for longer than 21 days in some specific circumstances (such as abscesses); prostatitis 2 to 4 weeks (acute) to 4 to 6 weeks (chronic). Other genito-urinary regimens in the same table: gonococcal urethritis and cervicitis 500 mg as a single dose (1 day); epididymo-orchitis and pelvic inflammatory disease 500 mg twice daily to 750 mg twice daily for at least 14 days. The SPC states the dosage is determined by the indication, the severity and site of infection, the susceptibility of the causative organism, the renal function of the patient and, in children and adolescents, body weight. The highest adult oral regimen appearing in the SPC table is 750 mg twice daily; no explicit adult maximum daily dose is stated in the retrieved text, so maxDose is omitted. In patients with impaired liver function no dose adjustment is required. In severe cases, or if the patient is unable to take tablets (e.g. patients on enteral nutrition), it is recommended to commence therapy with intravenous ciprofloxacin until a switch to oral administration is possible. Section 4.4 (special warnings) and section 4.8 (undesirable effects) were both cut off at the source-fetch limit in this bundle, and no section 4.5 (interactions) text was captured — the interaction entries below are taken from section 4.3 and from the method-of-administration paragraph in section 4.2, which cross-reference section 4.5. Clinician to verify the complete SPC before publication. The paediatric complicated UTI / pyelonephritis regimen is held in paedDose.

Paediatric population, complicated urinary tract infections and pyelonephritis (SPC section 4.2 table): 10 mg/kg body weight twice daily to 20 mg/kg body weight twice daily, with a maximum of 750 mg per dose, total duration 10 to 21 days. The SPC gives a range rather than a single per-kg figure, so dosePerKg is left null — the exact quoted range is 10 mg/kg to 20 mg/kg twice daily. Other paediatric regimens in the same table: cystic fibrosis 20 mg/kg twice daily (max 750 mg per dose) for 10 to 14 days; inhalation anthrax post-exposure prophylaxis 10 mg/kg to 15 mg/kg twice daily (max 500 mg per dose) for 60 days; other severe infections 20 mg/kg twice daily (max 750 mg per dose). Dosing in children with impaired renal and/or hepatic function has not been studied. Verify any under-18 use against a children's formulary.