Propantheline bromide
Brand names: Pro-Banthine
Propantheline bromide is an antimuscarinic (anticholinergic) agent that has been used for conditions including urinary frequency and detrusor instability, as well as gastrointestinal smooth muscle spasm and hyperhidrosis.
ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.
Clinical monograph
How it works
It is a quaternary ammonium antimuscarinic that competitively blocks acetylcholine at muscarinic receptors, reducing smooth muscle tone and secretions.
Prescribing in practice
- It is contraindicated in angle-closure glaucoma, significant bladder outflow or gastrointestinal obstruction and myasthenia gravis.
- Use with caution in older people, who are more susceptible to antimuscarinic adverse effects including confusion, constipation and urinary retention.
- It is best taken before food, as administration with food reduces its absorption.
Monitoring
Monitor for anticholinergic adverse effects and for symptom control, with particular attention to cognition and bowel and bladder function in older patients.
Counselling the patient
- Take the medicine before meals as directed.
- Expect a dry mouth and report difficulty passing urine, constipation or blurred vision.
Evidence & guidelines
It is a long-established antimuscarinic; consult the SPC and current prescribing references for licensed uses and cautions.
Reference: Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).
Related
Curated clinical cross-links plus same-class fallbacks.