Haematology
Multiple Myeloma — Diagnostic Workup
CRAB criteria, immunoglobulin / free light chains, bone marrow, imaging, induction therapy.
Source: BSH 2021; IMWG
Step 1 of ~6
info
Suspect — CRAB Features
Suspect in: bone pain (back), pathological fracture, hypercalcaemia (Ca ↑), AKI / unexplained renal failure, anaemia + ↑ ESR / plasma viscosity, recurrent infections (functional immunoparesis), neuropathy. CRAB criteria for symptomatic MM: hyperCalcaemia (>2.75), Renal impairment (creatinine >177 or eGFR <40), Anaemia (Hb <100 or 20 below LLN), Bone lesions (≥1 lytic lesion).
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Cladribine · Multiple Sclerosis — Disease-Modifying Therapy
- Propofol · Anaesthetic (IV Induction / Sedation)
- Thiopental Sodium · Barbiturate Induction Agent
- Etomidate · Imidazole Induction Agent
- Retinol palmitate with white soft paraffin, light liquid paraffin, liquid paraffin and wool fat · Ocular lubricant ointment
- Estradiol (HRT — Hormone Replacement Therapy) · Oestrogen Replacement Therapy
Pathways
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO
Decision support only. Always apply local guidelines and clinical judgement.