2023 Duke-ISCVID Criteria for Infective Endocarditis

≥2 positive blood cultures with typical organisms (Strep viridans, Strep bovis, HACEK, S. aureus, Enterococcus without primary focus) OR persistently positive cultures > 12h apart OR ≥3 of ≥4 positive cultures

Vegetation, abscess, pseudoaneurysm, fistula, valvular perforation, new valvular regurgitation, new prosthetic dehiscence on echo; OR CT/PET-CT showing abnormal activity around prosthetic valve or vascular graft

Prosthetic valve, prior IE, congenital heart disease, other predisposing condition, or IVDU

Major arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial haemorrhage, conjunctival haemorrhage, Janeway lesions

Glomerulonephritis, Osler nodes, Roth spots, positive rheumatoid factor

Positive blood culture not meeting major criteria, OR serological evidence of active infection with organism consistent with IE