CISNE — Clinical Index of Stable Febrile Neutropenia
Identifies low-risk solid-tumour patients with febrile neutropenia who can safely be discharged on oral antibiotics (Carmona-Bayonas 2015). Use only in haemodynamically stable patients without acute organ failure.
Score interpretation
→ Outpatient oral antibiotic regimen (e.g. amoxicillin-clavulanate + ciprofloxacin) with 24-h review safe in haemodynamically stable patients with reliable follow-up.
→ Admit for IV antibiotics (piperacillin-tazobactam) per local protocol; minimum 48 h observation.
→ Admit for full sepsis workup and broad-spectrum IV antibiotics. Consider G-CSF, antifungal cover if prolonged neutropenia. Critical care review if signs of shock.
Interpretation bands for the CISNE. Apply clinical judgement and local guidance.
References
Related
Curated clinical cross-links plus same-class fallbacks.
- Meropenem (Paediatric) · Carbapenem — Severe / MDR Gram-Negative Infections / Febrile Neutropenia
- Isosorbide Mononitrate (Stable Angina) · Nitrate / Stable Angina
- Nicorandil · Stable Angina
- Ranolazine · Refractory Stable Angina
- Zoledronic Acid · Bisphosphonate (IV)
- Denosumab · RANK Ligand Inhibitor (Anti-resorptive)
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.