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Local anaesthetic + antiseptic

Lidocaine with cetrimide

Lidocaine with cetrimide is a combined topical local anaesthetic and antiseptic preparation used to provide surface anaesthesia together with skin disinfection, for example before minor procedures.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

Lidocaine blocks sodium channels in superficial sensory nerve endings to produce local numbness, while cetrimide is a cationic surfactant antiseptic that disrupts microbial cell membranes.

Prescribing in practice

  • Apply only to the intended surface and avoid application to broken skin, mucous membranes or large or inflamed areas, as this increases lidocaine absorption and the risk of systemic toxicity.
  • Cetrimide can cause skin irritation and sensitisation, and is intended for external use only.
  • Keep away from the eyes and do not use on extensively damaged tissue.

Monitoring

Monitor the treated skin for irritation or hypersensitivity and, with extensive use, for any features of local anaesthetic systemic toxicity.

Counselling the patient

  • This preparation numbs and cleans the skin surface before a procedure.
  • It is for use on the skin only; avoid contact with the eyes.
  • Report any rash, marked stinging or swelling at the site.

Evidence & guidelines

Topical local anaesthetic-antiseptic combinations are used per their SPC for surface anaesthesia and skin disinfection.

Reference: Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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