Non-steroidal anti-androgen
Flutamide
Brand names: Drogenil
Adult dose
Dose: 250mg TDS
Route: PO
Frequency: TDS
Clinical pearls
- Prostate cancer (less commonly used now; bicalutamide preferred)
- Hepatotoxicity occurs early — check LFTs frequently in first 4 months
Contraindications
- Severe hepatic impairment
- Pregnancy/breastfeeding
Side effects
- Hepatotoxicity (potentially fatal — black box)
- Gynaecomastia
- Diarrhoea
- Photosensitivity
- Methaemoglobinaemia
Interactions
- Warfarin (raised INR)
- CYP1A2 substrates
Monitoring
- LFTs (monthly initially)
Reference: BNF; NICE NG131; https://bnf.nice.org.uk/drugs/flutamide/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Revised Original International Autoimmune Hepatitis Score (IAIHG) · Autoimmune Liver Disease
- Ho Index for Predicting Response to Medical Therapy in IBD · Inflammatory Bowel Disease
- Rh(D) Immune Globulin Dosage for Maternal-Fetal Haemorrhage · Haematology in Pregnancy
- AREDS Classification of Age-related Macular Degeneration · Macular Degeneration
- Diabetic Macular Oedema (DMO) Classification · Diabetic Retinopathy
- Retinopathy of Prematurity — International Classification (ICROP3) · Paediatric Retina
Pathways
- Acute Myeloid Leukaemia Presentation · BSH; NICE — NG146
- Tumour Lysis Syndrome · Cairo-Bishop; BSH; NICE — Best Practice
- Diabetic Ketoacidosis (DKA) · JBDS 2013 / Joint British Diabetes Societies; NICE NG17
- Adult Hypoglycaemia (Treated Diabetes) · JBDS-IP (2023): Hospital Management of Hypoglycaemia
- Adrenal Crisis · Society for Endocrinology Emergency Guidance (2024)
- Type 2 Diabetes Management · NICE NG28 2022