Amoxicillin

SOURCE: eMC UK SPC, productName 'Amoxicillin 250 mg/5 ml Powder for Oral Suspension Sugar Free' (https://www.medicines.org.uk/emc/product/14145/smpc), §4.2. The dose selected should take into account the expected pathogens and their likely susceptibility, the severity and site of the infection, and the age, weight and renal function of the patient. TABLE-FLATTENING CAVEAT: the fetched text flattens the SPC's two-column dose table, so every indication/dose pairing below must be confirmed against the table in the SPC itself before publishing. INDICATION-SPECIFIC ADULT DOSES (adults and children 40 kg or more), as listed: acute bacterial sinusitis, asymptomatic bacteriuria in pregnancy, acute pyelonephritis, dental abscess with spreading cellulitis — 250 mg to 500 mg every 8 hours or 750 mg to 1 g every 12 hours, and for severe infections 750 mg to 1 g every 8 hours; acute cystitis — may be treated with 3 g twice daily for one day; acute otitis media, acute streptococcal tonsillitis and pharyngitis, acute exacerbations of chronic bronchitis — 500 mg every 8 hours or 750 mg to 1 g every 12 hours, and for severe infections 750 mg to 1 g every 8 hours for 10 days; community acquired pneumonia — 500 mg to 1 g every 8 hours; typhoid and paratyphoid fever — 500 mg to 2 g every 8 hours; prosthetic joint infections — 500 mg to 1 g every 8 hours; prophylaxis of endocarditis — 2 g orally as a single dose 30 to 60 minutes before the procedure; Helicobacter pylori eradication — 750 mg to 1 g twice daily in combination with a proton pump inhibitor (e.g. omeprazole, lansoprazole) and another antibiotic (e.g. clarithromycin, metronidazole) for 7 days; Lyme disease early stage — 500 mg to 1 g every 8 hours up to a maximum of 4 g/day in divided doses for 14 days (10 to 21 days); Lyme disease late stage with systemic involvement — 500 mg to 2 g every 8 hours up to a maximum of 6 g/day in divided doses for 10 to 30 days. Consideration should be given to the official treatment guidelines for each indication. DURATION should be determined by the type of infection and the response of the patient and should generally be as short as possible. PAEDIATRIC (children weighing under 40 kg) — deliberately NOT structured into paedDose because the SPC gives indication-dependent RANGES rather than a single per-kg value, and a single figure would be an invention: acute bacterial sinusitis, acute otitis media, community acquired pneumonia, acute cystitis, acute pyelonephritis, dental abscess with spreading cellulitis — 20 to 90 mg/kg/day in divided doses; acute streptococcal tonsillitis and pharyngitis — 40 to 90 mg/kg/day in divided doses; typhoid and paratyphoid fever — 100 mg/kg/day in three divided doses. Twice daily dosing regimens should only be considered when the dose is in the upper range. Children weighing 40 kg or more should be prescribed the adult dosage. Amoxicillin paediatric suspension is recommended for children under six months of age. Verify all paediatric dosing against a children's formulary. ELDERLY: no dose adjustment is considered necessary. HEPATIC IMPAIRMENT: dose with caution and monitor hepatic function at regular intervals. SOURCE NOTE: §4.5 was not captured in this bundle (the §4.4 text is truncated at the source-fetch limit) and the openFDA provider is empty, so no interactions list is asserted in this draft — the clinician must review §4.5 in the SPC.