Fibrinogen (Specialist drug)

How it works

It replaces deficient fibrinogen, the precursor that is converted by thrombin to fibrin to form a stable blood clot and support haemostasis.

Prescribing in practice

• There is a risk of thromboembolism with fibrinogen replacement, so it should be used at the lowest effective level guided by the clinical situation and laboratory results.
• As a plasma-derived product, hypersensitivity reactions can occur and patients should be observed during administration.
• Use should be directed by a haematologist or specialist and guided by fibrinogen levels.

Monitoring

Monitor plasma fibrinogen levels and clinical bleeding to guide dosing, and observe for signs of thrombosis.

Counselling the patient

• Report any signs of a clot such as leg swelling, chest pain or breathlessness.
• Tell the team about any reaction during the infusion.
• This is a specialist treatment given and supervised by your haematology team.

Evidence & guidelines

Fibrinogen concentrate is established replacement therapy for fibrinogen deficiency and acquired hypofibrinogenaemia, with use guided by specialist haematology practice.