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NSAID (oxicam)

Piroxicam

Brand names: Feldene

Piroxicam is a long-acting non-steroidal anti-inflammatory drug (NSAID) of the oxicam class, used for inflammatory and degenerative joint disease where other options are unsuitable.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It inhibits cyclo-oxygenase, reducing prostaglandin synthesis and thereby producing anti-inflammatory and analgesic effects.

Prescribing in practice

  • Because of a higher risk of serious gastrointestinal and skin reactions, MHRA advice restricts piroxicam to second-line use in rheumatic disease, initiated only by specialists, and not for acute pain.
  • It carries the usual NSAID cardiovascular, renal, and bleeding risks and should be used at the lowest effective dose for the shortest time.
  • Gastroprotection should be considered, particularly in older patients or those with risk factors for ulceration.

Monitoring

Monitor renal function, blood pressure, and for gastrointestinal symptoms or signs of bleeding, especially in at-risk patients.

Counselling the patient

  • Take with or after food and report any indigestion, black stools, or signs of stomach bleeding.
  • Stop and seek urgent advice if any skin rash, blistering, or mouth ulceration develops.
  • Avoid other anti-inflammatory painkillers unless advised by your clinician.

Evidence & guidelines

MHRA review of piroxicam led to restricted indications and prescribing safeguards because of its gastrointestinal and dermatological risk profile.

Reference: MHRA; NICE; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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