Vinca alkaloid cytotoxic
Vinorelbine (Specialist drug)
Brand names: Navelbine
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV/PO (NEVER intrathecal IV — fatal)
Frequency: per protocol
Clinical pearls
- Advanced NSCLC, breast cancer
- Specialist oncology — IV NEVER intrathecal
Contraindications
- Severe myelosuppression
- Severe hepatic impairment
- Pregnancy
- Intrathecal route
Side effects
- Myelosuppression
- Peripheral neuropathy
- GI upset
- Alopecia
- Phlebitis
- Vesicant
Interactions
- Strong CYP3A4 modulators
- Live vaccines
Monitoring
- FBC
- LFTs
- Neurology
Reference: BNF; NICE TA181; SmPC; https://bnf.nice.org.uk/drugs/vinorelbine-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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