Vinca alkaloid cytotoxic
Vincristine sulfate (Specialist drug)
Brand names: Oncovin
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV (NEVER intrathecal — fatal)
Frequency: per protocol
Clinical pearls
- ALL, lymphomas, paediatric solid tumours
- NEVER intrathecal — fatal; pre-prescribe laxatives
Contraindications
- Demyelinating CMT disease
- Pregnancy
- Intrathecal route (fatal)
Side effects
- Peripheral neuropathy (dose-limiting)
- Constipation/paralytic ileus
- SIADH
- Cytopenias
- Vesicant
- Alopecia
Interactions
- Strong CYP3A4 modulators
- Phenytoin
- Live vaccines
Monitoring
- Neurology
- FBC
- Bowel function
Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/vincristine-sulfate-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Vancomycin Dosing Calculator · Drug Dosing
- Phenytoin Correction for Albumin / Renal Failure · Drug Dosing
- Local Anaesthetic Maximum Dose Calculator · Drug Dosing
- Tisdale Risk Score for QT Prolongation · Arrhythmia
- Bazett Corrected QT Interval (QTc) Calculator · Arrhythmia
- DAPT Score for Dual Antiplatelet Therapy Duration · Antiplatelet Therapy
Drugs
Pathways
- Acute Myeloid Leukaemia Presentation · BSH; NICE — NG146
- Tumour Lysis Syndrome · Cairo-Bishop; BSH; NICE — Best Practice
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH