Antimuscarinic (overactive bladder)
Oxybutynin hydrochloride
Brand names: Ditropan, Cystrin, Lyrinel XL
Adult dose
Dose: PO IR: 5mg BD-TDS (max 5mg QDS). MR: 5–20mg OD. Patch (Kentera): 36mg patch twice weekly
Route: PO/Transdermal
Frequency: BD-QDS or OD
Clinical pearls
- Mirabegron preferred in older adults to reduce cognitive risk
- MR / patch better tolerated
Contraindications
- Urinary retention
- GI obstruction
- Glaucoma
- Myasthenia gravis
- Severe ulcerative colitis
Side effects
- Dry mouth (very common)
- Constipation
- Confusion in elderly (avoid in dementia)
- Urinary retention
- Tachycardia
- Anticholinergic burden
Interactions
- Other antimuscarinics — additive cognitive/anticholinergic load
Reference: BNF; NICE NG123; https://bnf.nice.org.uk/drugs/oxybutynin-hydrochloride/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Drugs